However, much higher doses have been shown to be quite safe with no adverse affects other than increased drowsiness and appetite – it will make u hungry for solid foods. Dan Duchaine (who discovered ketos use for BB) suggested 10mg ED but in my experience this much is not needed and makes u far too sleepy. No studies have been done to find the most effective dose but the German researchers used 4 mg ED. Its primary side effects seem to be temporary drowsiness, dry mouth,(and other mucuos membranes) appetite stimulation and weight gain. People who took twenty times the recommended dose (in suicide attempts) suffered no serious consequences (other than embarrassment). Ketotifen is virtually non-toxic (although it is not advised for patients with epilepsy). Taking ketotifen for 12 weeks, these patients gained an average of six pounds, had increases in their body cell mass and reductions in their TNF-alpha levels. The other study used ketotifen fumarate by itself in eight patients with elevated TNF-alpha, (but no wasting). A larger placebo controlled study of this combination is underway. One study used ketotifen in combination with oxymethadone, a steroid like Megace that helps people gain weight, so it is hard to gauge what effect ketotifen had (the study notes a 14% reduction in TNF-alpha levels and weight gains of 11-12 pounds in less than four weeks). German researchers have published data showing that ketotifen lowers tnf-alpha in the test tube. Ketotifen also reduces edema (swelling and puffiness caused by water retention) around sores. A number of case studies suggest that it may be helpful treating skin problems such as acne. Ketotifen also protects the cells in the stomach, small intestine and perhaps the rest of the gut from a number of toxins. When used for asthma, weight gain and an increase in appetite are among the most frequent side effects. It is also being studied as a treatment for colitis. Ketotifen fumarate is very safe antihistamine used extensively in Europe to treat bronchial asthma and allergies.
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